|
ÉúÎï¹È±¨µÀ£º·Ñ³Ç¡ª-¶íº¥¶íÖÝÁ¢´óѧѧÕß·¢ÏÖÁ½ÖÖµÄ΢СRNA(miRNA)·Ö×Ó¿ØÖÆ×ÅÓëBϸ°ûÂýÐÔÁÜ°Íϸ°û°×Ѫ²¡£¨B-CLL£©µÄÒ»¸öΣÏÕÀàÐÍÓйصÄÒ»ÖÖ°©»ùÒò£¬ÕâÖÖ°×Ѫ²¡ÊÇÊÀ½çÉÏ×î³£¼ûµÄÈËÀà°×Ѫ²¡¡£ËûÃǵķ¢ÏÖ±»¿¯µÇÔÚ12ÔÂ15ºÅµÄ°©Ö¢Ñо¿ÆÚ¿¯ÉÏ£¬Ö¤Ã÷ÁËmiRNAÔÚ°©Ö¢½øÕ¹Ö®ÖÐ×÷Ϊǿ´óµÄ»ùÒò±í´ïµ÷¿ØÒò×Ó¶ø´æÔÚ£¬¿ÉÒÔΪҩÎïÖÎÁÆÌṩеİе㡣
ÕâЩmiRNAС·Ö×ÓÊǵ¥Á´RNA·Ö×Ó£¬¿ÉÒÔ×÷ΪÖ×ÁöÒÖÖÆÒò×Ó»òÕß°©»ùÒò¶øÆð×÷Óá£ËüÃÇ¿ÉÒÔͨ¹ý×èÖ¹»ùÒò²úÉúÐÅʹRNA×è°ÕâЩ»ùÒòµÄת¼£¬»òÕßͨ¹ý×è°ÐÅʹRNA²úÉúµ°°×ÒÖÖÆÕâЩ»ùÒòµÄ·Òë¡£½ñÄêÔçЩʱºò£¬Ñо¿ÕßÌá³öÁËmiRNA·Ö×Ó¹ý±í´ï¿ÉÒÔµ¼Ö°©Ö¢½øÕ¹µÄµÚÒ»¸öÖ±½ÓÖ¤¾Ý£¬È·ÈÏÁËһϵÁÐÓëBϸ°ûÂýÐÔÁÜ°Íϸ°û°×Ѫ²¡Ïà¹ØµÄmiRNA£¬ËüÃÇ¿ÉÒÔ´Ù½øÖ×Áö½øÕ¹¡£µ«ÊDZ£»¤ÐÔ»ùÒòmiR-29ºÍmiR-181×÷ΪĿǰΪֹ×îÖØÒªµÄmiRNA³öÏÖ£¬ÕâЩ΢СRNA¿ÉÄܱ»Ö¤Ã÷ÓëÎÒÃÇËùÖªµÄÄÜʹ»ùÒò¿ª·Å»ò¹Ø±ÕµÄµ°°×ת¼Òò×ÓÒ»Ñù¹¦ÄÜÇ¿´ó¡£
ÕâÁ½ÖÖ¸ßˮƽµÄmiRNA£¬°üÀ¨ÒÑÖªµÄmiR-29,miR-181,Ëƺõ¿ÉÒÔÒÖÖÆ°©»ùÒòTCL1µÄ±í´ï£¬ÕâÖÖ°©»ùÒò¿ØÖÆ×ÅÒ»¸ö¶ñÐԳ̶È×î¸ßµÄ°×Ѫ²¡ÀàÐÍ¡£Ñо¿ÈËÔ±·¢ÏÖÁËmiR-29¡¢miR-181ºÍ°©»ùÒòTCL1µÄ±í´ïÖ®¼ä´æÔÚÖ±½ÓµÄÏà·´ÁªÏµ£¬ËüÃÇÔÚÁ½¸ö·½ÏòÉÏÆð×÷Óã¬ÔÚ²»Ì«¿ÉÄܽøÕ¹µÄ¶èÐÔ°©ÖУ¬ÕâЩmiRNAµÄ¸ß±í´ïÓëTCL1µÄµÍ±í´ïÏà¹Ø¡£Òò´Ë£¬´Ù½øÕâÁ½ÖÖÌìÈ»TCL1ÒÖÖÆÒò×Ó²úÉúµÄÒ©Îï¿ÉÄܱ»ÓÃ×÷ΪһÖÖδÀ´ÖÎÁÆBϸ°ûÂýÐÔÁÜ°Íϸ°û°×Ѫ²¡µÄ·½·¨£¬ÕâЩ·Ö×ÓÒ²¿ÉÒÔÓë12ÖÖÆäËûmiRNA½áºÏ£¬ÕâЩmiRNAÓëBϸ°ûÂýÐÔÁÜ°Íϸ°û°×Ѫ²¡Óйأ¬¿ÉÒÔ×÷ΪһÖÖ²âÊÔ·½·¨ÒÔÅжÏÔ¤ºóºÍÖÎÁÆ·½·¨¡£
ÔÎijö´¦£º
Cancer Research December 15 2006, Volume 66, Issue 24
Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181
Yuri Pekarsky, Urmila Santanam, Amelia Cimmino, Alexey Palamarchuk, Alexey Efanov, Vadim Maximov, Stefano Volinia, Hansjuerg Alder, Chang-Gong Liu, Laura Rassenti, George A. Calin, John P. Hagan, Thomas Kipps, and Carlo M. Croce
Cancer Res 2006 66: 11590-11593. [Abstract] [Full Text] [PDF]
Ïà¹Ø»ùÒò£º
TCL1A
Official Symbol: TCL1A and Name: T-cell leukemia/lymphoma 1A [Homo sapiens]
Other Aliases: TCL1
Other Designations: T-cell lymphoma-1; T-cell lymphoma-1A
Chromosome: 14; Location: 14q32.1
MIM: 186960
GeneID: 8115
TCL1B
Official Symbol: TCL1B and Name: T-cell leukemia/lymphoma 1B [Homo sapiens]
Other Aliases: TML1
Other Designations: T-cell lymphoma/leukemia 1B; TCL1/ MTCP1-like 1
Chromosome: 14; Location: 14q32.1
MIM: 603769
GeneID: 9623
×÷Õß¼ò½é£º
Yuri Pekarsky, Ph.D.
Primary Appointment
Department of Molecular Virology, Immunology and Medical Genetics Human Cancer Genetics Program
For More Information:
Please visit Human Cancer Genetics
Ïà¹Ø±¨µÀ£º
ÃÀ¿Æѧ¼Ò·¢ÏÖ΢СRNA±í´ïµÄлúÖÆ
ÉÏһƪ£ºÃÀ·¢ÏÖ»ùÒòµ÷¿Ø¿É»ØÓ¦¡°RNAÊÀ½ç¡± ÏÂһƪ£ºGene Therapy£ºÄÏ¿ª´óѧÁ½Î»ÌØƸ½ÌÊÚÌá³ösiRNAвßÂÔ
|
