| 2006年12月14日 Nature中英文摘要 | | 点击： 作者：51protocol收集 来源： 时间： 2007-03-13 本站论坛 |
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December 14, 2006
Cytohesins与胰岛素抗性之间的关系
胰岛素抗性综合症是各种不同器官不能对胰岛素做出足够反应的一种症状，是二型糖尿病发病的一个主要危险因素。对绝大多数受影响的人来说，造成该症状的分子缺陷尚不清楚。现在，Hafner等人发现，Cytohesins（一类调控蛋白，以前被发现参与与胰岛素相关的代谢）的化学抑制能导致小鼠肝脏对胰岛素产生抵抗力。这表明，受损的Cytohesin功能是胰岛素抗性的一个可能的原因，Cytohesin的激发成分可用来治疗这种疾病。在另一项研究中，研究人员发现，果蝇体内与Cytohesin相当的Steppke是胰岛素信号作用的一个重要构成部分。这两篇论文一起为Cytohesins在胰岛素通道中所起的中心作用提供了独立证据，并且表明，通过Cytohesin对该通道的控制至少已有8亿年时间了。
Contents
Authors
Making the paper: Jin Meng pxv
How a fossil helped to redraw the mammalian family tree.
doi:10.1038/7121xva
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Abstractions pxv
doi:10.1038/7121xvb
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Key collaboration pxv
doi:10.1038/7121xvc
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Top of pageEditorials
Calmer waters ahead p789
A conviction, the passage of a bill, and the arrival of some new committee chairmen have markedly improved the immediate outlook for biomedical research in the United States.
doi:10.1038/444789a
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An open debate p789
Researchers who work with animals should join the discussion on animal experimentation.
doi:10.1038/444789b
Full Text | PDF (126K)
See also: Editor's summary
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The elephant in the room p790
A biotech trial that went awry.
doi:10.1038/444790a
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Top of pageResearch Highlights
Research highlights p792
doi:10.1038/444792a
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Top of pageNews
When good cholesterol turns bad p794
Pfizer's heart drug fails clinical trial.
Helen Pearson
doi:10.1038/444794a
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Changes at the helm fuel Salk expansion plans p794
California institute aims to build on its success.
Rex Dalton
doi:10.1038/444794b
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Agency set up to tackle bioterror p796
Last minute deals in Congress push through biodefence bill and give cash boost to NIH.
Meredith Wadman
doi:10.1038/444796a
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Snapshot: 'So far, so good' for shuttle p796
Night-time shuttle launch is a success.
Michael Hopkin
doi:10.1038/444796b
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Sidelines p797
doi:10.1038/444797a
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Australia lifts ban on cloning p799
Scientists hail move to allow more stem-cell research.
David Cyranoski
doi:10.1038/444799a
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Stem-cell techique 'contrary to public order' p799
Patent ruling tightens stem-cell restrictions in Germany.
Alison Abbott
doi:10.1038/444799b
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Martian gullies turn tide in hunt for life p800
Signs of liquid water prompt rethink for Mars exploration teams.
Katharine Sanderson
doi:10.1038/444800a
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A vision of life after Blair p801
Pre-budget report offers taste of Brown's premiership.
Jim Giles
doi:10.1038/444801a
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News in brief p802
doi:10.1038/444802a
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Correction p803
doi:10.1038/444803a
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