遗传表达“噪音”的持续观测
遗传上相同的细胞在一个给定的时间产生不同水平的一种给定的蛋白。遗传表达上的这种噪音，被认为与包括细胞命运的确定及抗药性的产生在内的各种不同重要过程有关。迄今为止，该现象只在微生物种群“短暂”地直接观测到。但本期Nature上发表的一项研究取得了突破，研究人员对人类癌细胞中这种噪音随时间的变化动态进行了跟踪观测，并对不同蛋白进行比较。该工作令人吃惊地显示了各个细胞状态的持久的“记忆”，这种记忆在培养中能持续两代以上。这一根本性的结果可能是人类细胞对药物的不同的、延迟的响应的基础。
Contents
Editorials
Our emperors have no clothes p519
The ITER fusion project demonstrates a solidity of purpose that is sorely lacking across the rest of the energy research spectrum.
doi:10.1038/444519a
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A little regulation p520
Regulators are beginning cautiously to navigate the uncharted waters of nanotechnology.
doi:10.1038/444520a
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Not the end of an era p520
The Mars squadron loses its commodore.
doi:10.1038/444520b
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Top of pageResearch Highlights
Research highlights p522
doi:10.1038/444522a
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Top of pageNews
Methane quashes green credentials of hydropower p524
Emissions from tropical dams can exceed fossil-fuel plants.
Jim Giles
doi:10.1038/444524a
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Preprint analysis quantifies scientific plagiarism p524
Physics papers reveal few serious breaches but some duplication.
Jim Giles
doi:10.1038/444524b
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Sidelines p526
doi:10.1038/444526a
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A space dilemma: extend missions or start afresh? p526
Loss of Mars probe prompts bout of soul searching.
Katharine Sanderson
doi:10.1038/444526b
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Amazon puts network power online p528
Cost-effective supercomputing wins academic praise.
Declan Butler
doi:10.1038/444528a
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Snapshot: A womb with a view p529
Sound waves showcase animal pregnancy.
Narelle Towie
doi:10.1038/444529a
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Past drought hints at Africa's future p529
History offers insight into climate patterns.
Michael Hopkin
doi:10.1038/444529b
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Japan speeds up nuclear physics p530
RIKEN's accelerator upgrade targets heavy-element synthesis.
Ichiko Fuyuno
doi:10.1038/444530a
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News in brief p531
doi:10.1038/444531a
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Top of pageBusiness
The bitterest pill p532
Drug companies lose hundreds of millions of dollars when large-scale human clinical trials fail. Helen Pearson examines whether alternative procedures could help avoid such disappointments.
doi:10.1038/444532a
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In brief p533
doi:10.1038/444533a
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Market Watch p533
Quirin Schiermeier
doi:10.1038/444533b
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Top of pageNews Features
In search of lost time p534
The ancient Antikythera Mechanism doesn't just challenge our assumptions about technology transfer over the ages — it gives us fresh insights into history itself.
doi:10.1038/444534a
Full Text | PDF (2,471K)
See also: Editor's summary
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Plantecology: The cost of leafing p539
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