Klotho基因是首次作为一种突变在一种小鼠身上发现的，该小鼠表现出一种综合征，很像人类的衰老，Klotho基因的过度表达能延长小鼠的寿命。哺乳动物身上也有抗衰老活性的证据。现在，研究人员已经发现了Klotho基因的一个可能的作用机制：它是一种主控分子（master molecule），将FGFR1(IIIc)（各种不同的、在不同功能层次上发挥作用的纤维原细胞生长因子的一个受体）转变成专门针对FGF23的一个受体，后者是来自骨头中的一种荷尔蒙，调控肾功能。
Contents
Editorials
Enough warheads, already p653
Its official: the reliability of existing US nuclear warheads makes their replacement unnecessary.
doi:10.1038/444653a
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See also: Editor's summary
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A fair share p653
The concept of sharing primary data is generating unnecessary angst in the psychology community.
doi:10.1038/444653b
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Green shoots of growth p654
Energy from biomass is an idea whose time has returned.
doi:10.1038/444654a
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Top of pageResearch Highlights
Research highlights p656
doi:10.1038/444656a
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Top of pageNews
Journal reveals plans to fight fraud p658
Science to select papers for extra-secure review process.
Meredith Wadman
doi:10.1038/444658a
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Molecular HIV evidence backs accused medics p658
DNA analysis indicates health workers were not to blame for infections.
Declan Butler
doi:10.1038/444658b
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US backs revamp of nuclear warheads p660
Weapons stockpile set for 'unnecessary' upgrade.
Geoff Brumfiel
doi:10.1038/444660a
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Bush faces rough ride over climate change p660
Courts and Congress poised to shape environment policy.
Emma Marris
doi:10.1038/444660b
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Sidelines p661
doi:10.1038/444661a
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South Africa takes steps to tackle HIV p663
Government finally faces up to pandemic.
Michael Cherry
doi:10.1038/444663a
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Oil firms back AIDS project in the Niger delta p663
Island community to be focus of anti-HIV initiative.
Colin Macilwain
doi:10.1038/444663b
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Purdue attacked over fusion inquiry p664
Physicists angry at apparent inertia in misconduct investigation.
Eugenie Samuel Reich
doi:10.1038/444664a
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Actions speak louder than images p664
Scientists warn against using brain scans for legal decisions.
Apoorva Mandavilli
doi:10.1038/444664b
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News in brief p667
doi:10.1038/444667a
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Top of pageBusiness Features
Introduction: Biofuelling the future p669
doi:10.1038/444669a
Full Text | PDF (363K)
See also: Editor's summary
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Sugar cane and ethanol: Drink the best and drive the rest p670
Brazil's sugar-cane ethanol industry is the world's best and able to get better, says Emma Marris.
Emma Marris
doi:10.1038/444670a
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US biofuels: A field in ferment p673
To move US biofuels beyond subsidized corn will be a challenge, reports Katharine Sanderson.
Katharine Sanderson
doi:10.1038/444673a
Full Text | PDF (2,406K)
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Liquid fuel synthesis: Making it up as you go along p677
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