February 01, 2007
TRPA1离子通道的激发机制
存在于痛觉神经元中的TRPA1离子通道会对有害的和刺激性的化合物做出反应，也会对寒冷做出反应。用小鼠做的基因剔除实验证实，TRPA1是一种生理上要求的痛觉传感器。如此多样的刺激何以激发TRPA1以前并不清楚，但Macpherson等人现在发现，TRPA1是被其半胱氨酸残体的共价修饰激发的。蛋白质被半胱氨酸活性试剂修饰并非不寻常，但这是第一次发现离子通道以这种方式被激发。TRPA1激发在对亲电性毒性和氧化性压力的响应中所起的作用也许是就可能发生的组织损伤向生物体发出警告。
February 01, 2007
与bicoid mRNA定位有关的特异性因子被发现
虽然bicoid mRNA（果蝇的前决定因子）是于1988年首次被定位的决定因子，但此前仍然不清楚它是怎样被定位在果蝇卵的前部的。现在，Uwe Irion 和 Daniel St Johnston已经识别出了这个神秘的特异性因子，它将RNA耦合到定位通道上，成为ESCRT-II复合物。ESCRT-II在对已经通过细胞内吞作用从细胞表面进入降解通道的蛋白质进行分类中起重要作用，并通过抑制生长因子受体来抑制肿瘤形成。但bicoid mRNA的定位是独立于内吞分类的，而且因为大鼠的ESCRT-II也结合RNA，所以mRNA定位中这一新颖的功能似乎在哺乳动物中被保留了下来。
Contents
Editorials
Brave blue world p459
Human spaceflight is no excuse for ignoring the home planet, which needs constant monitoring from space.
doi:10.1038/445459a
Full Text | PDF (89K)
See also: Editor's summary
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Defence deficit p459
A public debate about renewing Britain's nuclear weaponry is undermined by excessive secrecy.
doi:10.1038/445459b
Full Text | PDF (119K)
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A changing drug supply p460
Research cuts by the world's largest drug company reflect a challenging outlook for the industry.
doi:10.1038/445460a
Full Text | PDF (68K)
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Top of pageResearch Highlights
Research highlights p462
doi:10.1038/445462a
Full Text | PDF (423K)
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Top of pageNews
Blair under fire over Trident 'secrecy' p464
Government rebuffs expert advice on submarine fleet.
Jim Giles
doi:10.1038/445464a
Full Text | PDF (306K)
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California institute woos NIH stem-cell chief p464
James Battey is in the frame for president's job.
Meredith Wadman
doi:10.1038/445464b
Full Text | PDF (306K)
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Bush splashes out on ocean research p465
President offers marine science $140-million cash boost.
Emma Marris
doi:10.1038/445465a
Full Text | PDF (201K)
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Infertility researchers target uterus transplant p466
Surgeons optimistic operations could succeed.
Helen Pearson
doi:10.1038/445466a
Full Text | PDF (257K)
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Michigan lab axed as Pfizer cuts costs p466
Staff in shock as drug giant restructures research.
Meredith Wadman
doi:10.1038/445466b
Full Text | PDF (257K)
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Sidelines p468
doi:10.1038/445468a
Full Text | PDF (114K)
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Physicists plan search for the known unknowns p468
Experiments aim to force gravity into the equation.
Jenny Hogan
doi:10.1038/445468b
Full Text | PDF (228K)
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Volcano gets choke chains to slow mud p470
Geophysicists offer concrete proposal to stem East Java eruption.
David Cyranoski
doi:10.1038/445470a
Full Text | PDF (194K)
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News in brief p471
doi:10.1038/445471a
Full Text | PDF (140K)
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Correction p471
doi:10.1038/445471b
Full Text | PDF (140K)
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Top of pageBusiness
Display of flexibility p473
Physicists at the University of Cambridge are leading a revolution in how data can best be displayed. Katharine Sanderson reports.
Katharine Sanderson
doi:10.1038/445473a
Full Text | PDF (133K)
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