January 18, 2007
1918年的流感病毒本身的确厉害
1918年的“西班牙流感”疫情极为严重，导致大约5000万人死亡。但为什么该疫情破坏力如此之大？也许是因为缺少用来对抗二次感染的抗生素，也许是由于社会经济方面的因素。但用最近重建的1918年流感对非人类灵长目动物所做的实验感染表明，该病毒本身的致命性是一个重要因素。它实际上是对实验感染的非人类灵长目动物能够致命的惟一流感病毒。 此外，1918年的流感病毒（而不是传统的人类病毒）能抑制先天免疫反应。因为当前流行的H5N1病毒也能引起与1918年病毒所引起的类似的严重肺部感染，并且也能影响先天免疫反应，所以保护宿主免疫系统中这部分功能的干预措施，也许能够减轻这些流感病毒所造成的感染的严重程度。
January 18, 2007
弓形虫致病能力差异性之谜
原生动物“刚地弓形虫”（Toxoplasma gondii）能引起细胞内感染，而病情严重程度则相差极大，既有不可避免的死亡，又有基本没有症状的情况，也有慢性感染。造成这种差异性的原因一直有点像谜一样，但现在研究人员已经识别出了有可能解释该现象的一种酶。研究发现，弓形虫能向宿主细胞中注入一种蛋白激酶，该激酶会被迅速转送进细胞核，在那里它会大大改变基因表达，包括决定宿主对感染反应的基因。不同类别的弓形虫有不同版本的这种蛋白，这有可能解释其致病能力为什么有很大差异。
Contents
Editorials
Leading by example p229
The primary safeguard against scientific misconduct is the example set every day by thousands of senior researchers in the laboratory.
doi:10.1038/445229a
Full Text | PDF (84K)
--------------------------------------------------------------------------------
The database revolution p229
Funding agencies face conflicting challenges in supporting the databases essential to modern biology.
doi:10.1038/445229b
Full Text | PDF (118K)
--------------------------------------------------------------------------------
Capitol calling p230
A fresh perspective on science and politics.
doi:10.1038/445230a
Full Text | PDF (70K)
--------------------------------------------------------------------------------
Top of pageResearch Highlights
Research highlights p232
doi:10.1038/445232a
Full Text | PDF (400K)
--------------------------------------------------------------------------------
Top of pageNews
Europe moves to secure its future energy supply p234
Commission proposes common policy to tackle climate change.
Quirin Schiermeier
doi:10.1038/445234a
Full Text | PDF (370K)
--------------------------------------------------------------------------------
Palaeontology journal will 'fuel black market' p234
Academics say published fossil finds should be available for study.
Michael Hopkin
doi:10.1038/445234b
Full Text | PDF (370K)
--------------------------------------------------------------------------------
Concern as revived 1918 flu virus kills monkeys p237
Questions raised over safety of revived microbe.
Kerri Smith
doi:10.1038/445237a
Full Text | PDF (165K)
--------------------------------------------------------------------------------
Sidelines p237
doi:10.1038/445237b
Full Text | PDF (165K)
--------------------------------------------------------------------------------
Behind the hunt for the Higgs boson p239
Race to find elusive particle steps up a gear.
Jenny Hogan
doi:10.1038/445239a
Full Text | PDF (170K)
--------------------------------------------------------------------------------
Misconduct? It's all academic... p240
The legal quagmire, strain and bad press of misconduct investigations leave many universities tempted to ignore misconduct allegations. But getting an investigation right can reduce the pain and boost an institution's reputation, says Geoff Brumfiel.
doi:10.1038/445240a
Full Text | PDF (664K)
--------------------------------------------------------------------------------
Breeding cheats p242
Understanding the social and psychological factors behind scientific misconduct will enable bad practice to be minimized, but never eliminated, says Jim Giles.
doi:10.1038/445242a
Full Text | PDF (452K)
--------------------------------------------------------------------------------
Where are they now? p244
Nature catches up with some past fraud investigations — and finds that, whether researchers are found to be guilty or innocent, the wounds are slow to heal.
Lucy Odling-Smee, Jim Giles, Ichiko Fuyuno, David Cyranoski and Emma Marris
doi:10.1038/445244a
Full Text | PDF (253K)
--------------------------------------------------------------------------------
News in brief p247
doi:10.1038/445247a
Full Text | PDF (118K)
--------------------------------------------------------------------------------
Top of pageColumn
Climate of opportunity p248
With the shift of power in the US Congress comes an chance to re-engage in the debate over climate change. But the process will not be simple, says our new columnist David Goldston.
上一篇：2007年02月01日 Nature中英文摘要 下一篇：2007年01月25日 Nature中英文摘要
共6页: 上一页 [1] 2 [3] [4] [5] [6] 下一页
|
