The Biochemistry of Cell Signalling

The Biochemistry of Cell Signalling
Ernst J. M. Helmreich
ISBN13: 9780198508205
paper, 368 pages
Sep 2001
Oxford University Press

General description This will serve as a reliable map through the maze of cell signaling pathways and help the reader understand how malfunctions in these pathways can lead to disease. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. Part 2 describes the implementation of the signaling cascades focusing on the effect on gene transcription. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer

Table of Contents

Part I: The machinery of signal transduction 1. Molecular basis of signal transduction
2. Activation of receptors by oligomerization
3. Components of signaling networks: linkers and regulators
4. Signal transduction pathways through small monomeric G proteins
5. Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals
6. Signal transduction pathways through morphogenesis and haematopoiesis
7. Control of signaling by phosphorylation and dephosphorylation
8. Regulation by a hormone: the insulin response
Part II: Cell Signaling and gene transcription 9. Machinery of Gene transcription
10. Regulation of gene transcription by growth factors and cytokines
11. Regulation of gene transcription by hormones
Part III: Global cell regulatory programs 12. Regulation of the cell cycle
13. Regulation of cell death
14. Regulation of the immune response
Part IV: Loss of regulatory control and its consequences
15. Transformation of normal cells to tumour cells
16. Loss of developmental controls in cancer
17. The causes of cancer
Glossary

http://sci-lib.com/books/H/helmreich.djvu