Review
Praise for the Series
"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."
--ENZYMOLOGIA
"This book is strongly recommended for researchers, teachers, students, administrators-in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inclusion in the scientist's personal library."
--JOURNAL OF MEDICINAL CHEMISTRY
"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."
--JOURNAL OF PHARMACEUTICAL SCIENCES --This text refers to the Paperback edition.
Book Description
Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Sections I-IV are disease orientated and generally report on specific medicinal agents.
Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design.
* Annual comprehensive reviews of the past year literature in many topics of interest to medicinal chemists
* Includes a comprehensive set of indices to easily locate topics in Volumes 1-38 of this series
* Provides critical review on hot topics in medicinal chemistry
Table of Contents
1 Attention deficit hyperactivity disorder : pathophysiology and design of new treatments 3
2 Ionotropic GABA receptors as therapeutic targets for memory and sleep disorders 13
3 Melatonin agonists for the treatment of sleep disorders and major depression 25
4 Recent advances in therapeutic approaches to type 2 diabetes 41
5 Recent progress in histamine H[subscript 3] receptor chemistry 57
6 Anti-resorptive and anabolic bone agents 67
7 Inhibition of the cysteine protease cathepsin K (EC 3.4.22.38) 79
8 Nonpeptide gonadotropin releasing hormone antagonists 99
9 Bradykinin B2 antagonists for the treatment of pain 113
10 Selective cyclooxygenase-2 inhibitors 125
11 The discovery of small molecule C5a antagonists 139
12 CCR1 antagonists 149
13 Recent advances in antimetabolite cancer chemotherapies 161
14 Mitotic kinesin inhibitors as novel anti-cancer agents 173
15 Recent advances in medicinal chemistry of histone deacetylase inhibitors 185
16 Therapeutic opportunities for the treatment of biofilm-associated infections 197
17 Biowarfare pathogens : is the research flavor different than that of clinically relevant pathogens? 211
18 HCV anti-viral agents 223
19 Pleiotropic effects of statins 241
20 Comparative protein structure modeling and its applications to drug discovery 259
21 Drug transporters and their role in tissue distribution 279
22 The hit-to-lead process in drug discovery 293
23 Prodrug strategies in the design of nucleoside and nucleotide antiviral therapeutics 305
24 Pre-clinical assessment of drug-induced QT interval prolongation : current issues and impact on drug discovery 323
25 To market, to market - 2003 335
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